Evidence map›Paper›PMID 42322609›Full record

ArticleCell reports2026

Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.

Michael P Zimmerman, Mowen Yin, Kevin R Cragg, Sanghamitra Nareddula, Varun M Kumar, Violeta Saldarriaga, Adriana Rotger, Rachel Lehman, Paige Edens, Caroline Powell and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael P ZimmermanDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA; Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Mowen YinDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA; Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Kevin R CraggDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA; Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Sanghamitra NareddulaDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Varun M KumarDepartment of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA.
Violeta SaldarriagaDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Adriana RotgerDepartment of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Rachel LehmanDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Paige EdensDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Caroline PowellDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Jenna BarryDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Sein KimDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Joseph G MakinDepartment of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA.
Alexander A ChubykinDepartment of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA; Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA. Electronic address: chubykin@purdue.edu.

Funding

Neural Mechanisms of Predictive Impairments in AutismR01MH116500 · NIMH · PURDUE UNIVERSITY · PI Alexander Chubykin · 2017 to 2026
$3.8M
NIMH NIH HHS R01 MH116500
6 · The paper itself

Abstract

Fragile X syndrome (FX) is associated with sensory processing and learning deficits. Visual familiarity evokes persistent theta oscillations during passive stimulus presentation in the primary visual cortex (V1) and the hippocampus (HPC), which are impaired in V1 of FX. How does this activity change during active behavior? To address this, we performed Neuropixels recordings in V1, HPC, and the prefrontal cortex (PFC) during Go/No-Go visual discrimination behavior. Theta oscillations are reduced in FX in both V1 and HPC and are abolished during No-Go trials, correlating with excessive, incorrect licking behavior. In wild-type (WT) mice, V1 theta power strongly correlates with correct behavioral outcomes. PFC shows significantly reduced cue-related responses in FX. Together, these findings show loss of behavioral inhibition in FX correlated with attenuated theta activity in V1 and HPC and deficient top-down control from PFC. This work sheds light on circuit-level impairments underlying behavioral deficits in FX for potential therapeutic interventions.

Indexed as

Behavior, AnimalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeTheta RhythmVisual CortexAnimalsHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutPrefrontal CortexFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1autismCP: neurosciencefragile X syndromehippocampuslearningmemoryneural circuitsprefrontal cortexprimary visual cortexvision

Identifiers

PMID42322609
PMCPMC13472280

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.