Evidence map›Paper›PMID 42322590›Full record

ArticlePest management science2026

Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura.

Yingdan Xiao, Xue Yang, Jianqiu Liu, Shaopeng Hao, Yajing Xu, Yue Chen, Huizhen Guo, Qingyou Xia, Marian R Goldsmith, Guy Smagghe and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yingdan XiaoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.ORCID https://orcid.org/0009-0009-0054-8686
Xue YangIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Jianqiu LiuIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Shaopeng HaoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Yajing XuDepartment of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.ORCID https://orcid.org/0000-0001-7445-4855
Yue ChenIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Huizhen GuoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Qingyou XiaIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.
Marian R GoldsmithDepartment of Biological Sciences, College of the Environment and Life Sciences, University of Rhode Island, Kingston, RI, USA.
Guy SmaggheInstitute of Entomology, Guizhou University, Guiyang, China.ORCID https://orcid.org/0000-0001-8334-3313
Kazuei MitaIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Chongqing Technology Innovation Center of Breeding, Biological Science Research Center, Southwest University, Chongqing, China.

Funding

Grant No. 2022YFD1201600(No. WO20125500074
6 · The paper itself

Abstract

backgroundPlants have evolved abundant defensive secondary metabolites to resist insect herbivores. Lycorine is an alkaloid with insecticidal activity from Amaryllidaceae plants, which the destructive pest Spodoptera litura naturally avoids. Cytochrome P450 enzymes are central to xenobiotic detoxification in insects, but the mechanism by which lycorine acts against S. litura remains unknown. This study aimed to reveal the toxic mechanism of lycorine focusing on P450-mediated detoxification.

resultsLycorine exhibited substantial toxicity to first-instar S. litura larvae (LD

conclusionsThese results demonstrate that the insecticidal mechanism of Lyc involves suppressing the expression and function of a CYP6AE gene cluster, thereby impairing detoxification capacity, which leads to Lyc accumulation and larval mortality. Elucidation of the detoxification system-targeted mechanism for this plant-derived compound provides a foundation for developing novel, sustainable pest management strategies against S. litura and potentially other noctuid pests. © 2026 Society of Chemical Industry.

Indexed as

Amaryllidaceae AlkaloidsCytochrome P-450 Enzyme SystemCytochrome P450 Family 6InsecticidesInsect ProteinsMultigene FamilyPhenanthridinesSpodopteraAnimalsDown-RegulationLarvaMalpighian TubulesAmaryllidaceae AlkaloidsCytochrome P-450 Enzyme SystemCytochrome P450 Family 6InsecticidesInsect ProteinslycorinePhenanthridinesaction mechanismcytochrome P450lycorineMalpighian tubuleoxidative stressSpodoptera litura

Identifiers

PMID42322590
PMCPMC13569397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.