Evidence map›Paper›PMID 42322542›Full record

ArticleClinical rheumatology2026

Clinical characteristics and disease activity of Spondyloarthritis in Central Vietnam: a cross-sectional study.

Hoang Thanh Van Nguyen, Thi Hoai Huong Vo, Cong Toan Le, Thi Thuy Trang Nguyen, Thi Kieu Oanh Nguyen

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Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Hoang Thanh Van NguyenDepartment of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen Street, Hue City, Vietnam. nhtvan@huemed-univ.edu.vn.ORCID http://orcid.org/0000-0001-7770-2949
Thi Hoai Huong VoDepartment of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen Street, Hue City, Vietnam.ORCID http://orcid.org/0009-0003-5910-1703
Cong Toan LeDepartment of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen Street, Hue City, Vietnam.
Thi Thuy Trang NguyenDepartment of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen Street, Hue City, Vietnam.
Thi Kieu Oanh NguyenDepartment of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen Street, Hue City, Vietnam.

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6 · The paper itself

Abstract

introductionSpondyloarthritis (SpA) is a major cause of chronic pain and disability worldwide; however, clinical characterization remains limited in Southeast Asia, particularly in low- and middle-income countries. This study aimed to describe the epidemiological and clinical characteristics of SpA in Central Vietnam.

methodsWe conducted a cross-sectional study of patients diagnosed with SpA according to the Assessment of SpondyloArthritis International Society criteria from 2019 to 2024. Disease activity was evaluated using the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) and the Patient Global Assessment (PGA). Factors associated with ASDAS-CRP and PGA score were explored using linear regression models.

resultsBased on an analaysis of 177 patients with SpA, the following results were observed. Most patients (148) had axial SpA, while 29 (16.4%) had peripheral SpA. Males accounted for 66.7% of cases, and 95.5% were diagnosed before the age of 45 years. The mean ASDAS-CRP and PGA scores were 2.8 ± 1.1 and 5.1 ± 2.1, respectively. Overall, 57% of patients exhibited high or very high disease activity. Higher ASDAS-CRP scores were significantly associated with male sex, presence of enthesitis, CRP ≥ 5 mg/L, ESR ≥ 10 mm/h, and absence of anemia. Higher PGA scores were significantly associated with older age at diagnosis, presence of enthesitis, chronic enteritis, CRP ≥ 5 mg/L, and absence of anemia.

conclusionThis study highlights a male predominance and a higher proportion of axial over peripheral SpA in Central Vietnam. Most patients presented with moderate to high disease activity. These findings emphasize the need for early diagnosis and management, as well as larger multi-center studies to better define the epidemiology and clinical patterns of SpA in Vietnam. Key Points • Provides the first comprehensive clinical characterization of spondyloarthritis (SpA) in Central Vietnam. • Reveals a clear predominance of axial SpA and male patients in the Vietnamese population. • Identifies factors associated with higher disease activity using both ASDAS-CRP and Patient Global Assessment. • Emphasizes the need for early diagnosis and multicenter studies to improve SpA management in Southeast Asia.

Indexed as

SpondylarthritisAdultC-Reactive ProteinCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexVietnamYoung AdultC-Reactive ProteinASASAxial spondyloarthritisDMARDsHLA-B27Peripheral spondyarthritisSpondyloarthritis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.