ArticleActa neurochirurgica2026
Intracranial pressure changes and outcomes in the early phase of experimental subarachnoid hemorrhage: severity of subarachnoid hemorrhage and maximum intracranial pressure.
Article in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the correlation between intracranial pressure (ICP) and the outcomes in rat subarachnoid hemorrhage (SAH) model and determine whether maximum ICP can predict severity of SAH.
methodsSprague-Dawley rats underwent the monofilament puncture procedure to induce SAH, and were divided into 4 groups according to the maximum ICP for survival prediction: sham group, mild ICP group (ICP < 50 mmHg), moderate ICP group (ICP 50-149 mmHg), and severe ICP group (ICP ≥ 150 mmHg).
resultsMaximum ICP showed strong correlations with the neurological score, SAH grade at 24 h after induction, and mortality. Histological study demonstrated that greater increase in maximum ICP was associated with worse outcome and more severe neuronal damage, apoptosis, and oxidative stress in the brain cortex and hippocampus at 24 h after induction.
conclusionThe present study demonstrates that monitoring the ICP can confirm the induction of SAH and classify individual cases into severity grade. Animals with maximum ICP of 50-149 mmHg may be the most suitable for the experimental study of SAH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.