Trial reportLasers in medical science2026
Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial.
Trial report in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
purposeTo evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). MATERIALS AND
methodsThis randomized, double-blind, parallel-group clinical trial included participants with DH who were allocated into four groups: laser group (LG), arginine group (AG), combined laser and arginine group (LAG), and control group (CG). Clinical assessments were performed at baseline and after 2, 4, and 8 weeks. DH was evaluated using evaporative (air stimulus) and tactile tests applied to the cervical-buccal surface of the teeth, with pain intensity recorded using the Visual Analog Scale (VAS). Linear mixed-effects models were used for longitudinal continuous outcomes (Schiff and VAS scores), while generalized estimating equations were applied for tactile sensitivity outcomes, adopting a significance level of 5%.
resultsA total of 60 participants were enrolled, and 54 completed the study. A significant reduction in DH was observed over time for both Schiff scores and VAS values (p < 0.001). Mean Schiff scores decreased from 5.0 (± 0.8) at baseline to 1.9 (± 1.3) at 8 weeks, while VAS scores also showed significant reductions. All groups demonstrated improvement in DH symptoms; however, no statistically significant differences were observed between interventions at any time point (p > 0.05).
conclusionsAll evaluated therapies were effective in reducing DH over the 8-week follow-up period, with a progressive reduction in symptoms over time. However, no statistically significant differences were observed between the interventions, and no additive effect was identified for the combined therapy. CLINICAL
trial registrationBrazilian Clinical Trials Registry ReBEC; RBR2vxzvkz, October 13
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