Evidence map›Paper›PMID 42322406›Full record

ArticleSurgery today2026

Clinical significance of the C-reactive protein-albumin-lymphocyte index in older patients with colorectal cancer.

Daiki Matsubara, Miki Tanaka, Atsuhito Ando, Atsushi Matsumura, Satoshi Mochizuki, Koji Miyagawa, Nobuaki Fuji, Atsushi Shiozaki

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Daiki MatsubaraDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan. daiki425@koto.kpu-m.ac.jp.
Miki TanakaDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Atsuhito AndoDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Atsushi MatsumuraDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Satoshi MochizukiDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Koji MiyagawaDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Nobuaki FujiDepartment of Surgery, Kyoto Saiseikai Hospital, 101 Shimouchida, Shimo-kaiinji, Nagaokakyo City, 617-8617, Kyoto, Japan.
Atsushi ShiozakiDivision of Digestive Surgery Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, 624-0906, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and long-term prognosis and postoperative complications in older patients with colorectal cancer (CRC).

methodsThree hundred three patients with pathological stage (pStage) I-III CRC who underwent curative surgery at our institution between 2015 and 2022 were retrospectively analyzed. Patients aged ≥ 75 years were defined as older.

resultsIn the overall cohort, a low CALLY index was an independent prognostic factor (hazard ratio (HR) = 2.42, 95% confidence interval (CI): 1.31-4.47, p = 0.004). The age-stratified analysis revealed that a low CALLY index was associated with a worse prognosis and was an independent prognostic factor in older patients (HR = 3.46, 95% CI: 1.44-8.30, p = 0.005), whereas no independent prognostic significance was observed in non-older patients. Moreover, although the CALLY index was not associated with postoperative complications in non-older patients, a low CALLY index was an independent risk factor for postoperative complications in older patients (odds ratio = 3.93, 95% CI 1.49-10.3, p = 0.005).

conclusionThe CALLY index is a valuable predictor of both short- and long-term outcomes in patients with pStage I-III CRC, with a particularly strong impact on older patients aged ≥ 75 years.

Indexed as

Biomarkers, TumorColorectal NeoplasmsC-Reactive ProteinLymphocytesPostoperative ComplicationsSerum AlbuminAgedAged, 80 and overAge FactorsClinical RelevanceColorectal Surgical ProceduresFemaleHumansLymphocyte CountMaleNeoplasm StagingBiomarkers, TumorC-Reactive ProteinSerum AlbuminColorectal cancerC-reactive protein-albumin-lymphocyte indexOlder patients

Identifiers

PMID42322406

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