Evidence map›Paper›PMID 42322096›Full record

SynthesisAnnals of medicine2026

Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.

Liaoyao Wang, Yuejie Lu, Hejing Pan, Xuanlin Li, Le Luo

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liaoyao WangHangzhou Wuyunshan Hospital (Hangzhou Institute for Health Promotion), Hangzhou, China.
Yuejie LuThe First Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, China.
Hejing PanSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Xuanlin LiSchool of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-8953-971X
Le LuoHangzhou Wuyunshan Hospital (Hangzhou Institute for Health Promotion), Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis meta-analysis aimed to evaluate the association between endometriosis (EM) and cardiovascular disease (CVD) risk by synthesizing evidence from large-scale cohort studies, with emphasis on subtype-specific risks and geographic disparities.

methodsWe systematically searched PubMed, Embase, and Cochrane Library for cohort studies published until December 2024. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using random-effects models. Subgroup analyses stratified CVD subtypes (e.g. ischemic heart disease, atrial fibrillation), continents, and country development levels. Heterogeneity and publication bias were assessed

resultsEleven cohort studies (

conclusionsEM is independently associated with an elevated risk of CVD, particularly for coronary artery disease and myocardial infarction. These findings underscore the need for targeted cardiovascular monitoring in EM patients, particularly in high-risk populations.

Indexed as

Cardiovascular DiseasesEndometriosisCohort StudiesFemaleHeart Disease Risk FactorsHumansMyocardial InfarctionRisk Factorscardiovascular diseasecoronary artery diseaseEndometriosisheart failuremeta-analysismyocardial infarction

Identifiers

PMID42322096
PMCPMC13288533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.