Evidence map›Paper›PMID 42322023›Full record

Observational studyJournal of viral hepatitis2026

HERACLIS_BLV_D: Adherence to Real-Life Therapy With Bulevirtide in Chronic Hepatitis D.

Dimitra Lakiotaki, Margarita Papatheodoridi, Vasilios Sevastianos, Kalliopi Zachou, Dimitrios Christodoulou, John Koskinas, Melanie Deutsch, Alexandra Alexopoulou, Ioannis Elefsiniotis, Christos Triantos and 29 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Journal of viral hepatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05928000 (Hellenic Multicenter Real-life Clinical Study for Bulevirtide Therapy in Chronic Hepatitis D), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05928000 unknown statusnot on this map

Hellenic Multicenter Real-life Clinical Study for Bulevirtide Therapy in Chronic Hepatitis D: HERACLIS-BLV

Typeobservational_patient_registrySponsorUniversity of AthensRan2023 to 2023Enrolled80ConditionsHepatitis DArmsBulevirtide
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Dimitra LakiotakiGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.
Margarita PapatheodoridiGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.
Vasilios SevastianosGeneral Hospital of Athens "Evangelismos", Athens, Greece.
Kalliopi ZachouGeneral University Hospital of Larissa, Larissa, Greece.
Dimitrios ChristodoulouUniversity General Hospital of Ioannina, Ioannina, Greece.
John KoskinasGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Melanie DeutschGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Alexandra AlexopoulouGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Ioannis ElefsiniotisGeneral and Oncology Hospital of Kifisia "Agioi Anargyroi", Athens, Greece.ORCID https://orcid.org/0000-0002-8118-7190
Christos TriantosUniversity General Hospital of Patras, Patras, Greece.
Elena GigiGeneral Hospital of Thessaloniki "Hippokratio", Aristotle University of Thessaloniki, Thessaloniki, Greece.
Theodoros AndroutsakosGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-2556-6230
Dimitrios S KaragiannakisGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.
Iliana ManiGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-9971-5174
Dimitrios DimitroulopoulosAgios Savvas Hospital, Athens, Greece.
Maria MelaGeneral Hospital of Athens "Evangelismos", Athens, Greece.
Emmanouil SinakosGeneral Hospital of Thessaloniki "Hippokratio", Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0003-0923-050X
Spyros MichopoulosGeneral Hospital of Athens "Alexandras", Athina, Greece.
Konstantinos MimidisUniversity General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Nikolaos PapadopoulosGeneral Army Hospital of Athens, Athina, Greece.
Athanasios KontosAgios Savvas Hospital, Athens, Greece.
Christos VeretanosGeneral Hospital of Athens "Evangelismos", Athens, Greece.
Dimitrios LymperopoulosGeneral Hospital of Athens "Evangelismos", Athens, Greece.
George GiannoulisGeneral University Hospital of Larissa, Larissa, Greece.
Vasilios PapadimitropoulosGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Evdoxia AvramopoulouUniversity General Hospital of Patras, Patras, Greece.
Alkistis PapatheodoridiGeneral Hospital of Athens "Alexandras", Athina, Greece.
Spyridon PantziosGeneral and Oncology Hospital of Kifisia "Agioi Anargyroi", Athens, Greece.
Larisa VasilievaGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Hariklia KranidiotiGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Emmanouil KoulliasGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Athanasios SoukovelosUniversity General Hospital of Ioannina, Ioannina, Greece.
Paraskevi FytiliGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.
John VlachogiannakosGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-3680-8194
Evangelos CholongitasGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.
Spilios ManolakopoulosGeneral Hospital of Athens "Hippokratio", Medical School of National and Kapodistrian University of Athens, Athens, Greece.
Ioannis GoulisGeneral Hospital of Thessaloniki "Hippokratio", Aristotle University of Thessaloniki, Thessaloniki, Greece.
George DalekosGeneral University Hospital of Larissa, Larissa, Greece.
George PapatheodoridisGeneral Hospital of Athens "Laiko", Medical School of National & Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-3518-4060

Funding

Gilead Sciences
6 · The paper itself

Abstract

Daily subcutaneous bulevirtide (BLV) 2 mg has been approved as first-line treatment for chronic hepatitis D (CHD), but long-term real-world adherence data are limited. We assessed adherence rates during BLV therapy and their impact on treatment response. HERACLIS_BLV_D study (NCT05928000) included adult CHD patients initiating BLV 2 mg/day and followed in routine clinical practice. Virological response (VR) was defined as HDV RNA < 57.5 IU/mL or decline > 2 log

Indexed as

Antiviral AgentsDrug MonitoringHepatitis D, ChronicAdultAgedFemaleHumansLipopeptidesMaleMiddle AgedRNA, ViralTreatment OutcomeViral LoadAntiviral AgentsbulevirtideLipopeptidesRNA, Viraladherencebulevirtidechronic hepatitis Dreal‐world study

Identifiers

PMID42322023
PMCPMC13282446

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.