ArticleInternational endodontic journal2026
Chronic Stress Predictability Modulates the Severity of Apical Periodontitis Induced in Wistar Rats.
Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
aimTo evaluate the effects of predictable and unpredictable chronic stress on the development and severity of periapical lesions in rats. METHODOLOGY: Thirty-two male Wistar rats were randomly allocated into four groups (n = 8 each): control, apical periodontitis without stress, apical periodontitis with predictable stress, and apical periodontitis with unpredictable stress. Emotional stress protocols were applied for 42 days, and apical periodontitis was induced on day 21 by pulp exposure. Stress induction was confirmed through behavioural evaluation using the open field and Y-maze tests. The severity of periapical lesions was assessed by microcomputed tomography and histological analysis. Data were analysed using Student's t-test, Mann-Whitney, one-way ANOVA, or Kruskal-Wallis tests (p < 0.05).
resultsBehavioural tests confirmed successful stress induction, with both stressed groups demonstrating reduced exploratory activity compared to non-stressed animals. Animals exposed to unpredictable stress developed significantly larger periapical lesions and exhibited higher inflammatory infiltrate scores than those subjected to predictable stress or no stress (p < 0.05). Microcomputed tomography findings corroborated the histological results, confirming the greater severity of apical periodontitis in the unpredictable stress group (p < 0.05).
conclusionUnpredictable chronic stress significantly exacerbated the development and severity of periapical lesions, suggesting that stress predictability may act as a modulatory factor in apical periodontitis progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.