Assessing metabolic flexibility in adults under physiological conditions: Effects of dietary fat and exercise in whole-room calorimetry.

Carmen P Ortega-Santos, Edward L Melanson, Daniel H Bessesen, Pan Zhaoxing, Corey A Rynders, Audrey Bergouignan

Abstract read

In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carmen P Ortega-SantosExercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.ORCID https://orcid.org/0000-0002-0071-1190

Edward L MelansonDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Anschutz Health and Wellness Center, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.

Daniel H BessesenDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Anschutz Health and Wellness Center, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.

Pan ZhaoxingDepartment of Biostatistics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Corey A RyndersDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Audrey BergouignanDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Anschutz Health and Wellness Center, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-1266-5144

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011

$61.3M

6 · The paper itself

Abstract

Metabolic flexibility (MetaFlex) reflects the ability to adjust substrate oxidation to changes in fuel availability and energy demand. How MetaFlex should be assessed under physiologically relevant metabolic challenges remains unclear. Data from two studies were analyzed in adults with contrasting adiposity and training status, known to influence MetaFlex: healthy lean inactive or trained adults (Ln-inactive/Ln-trained, BMI: 19-25 kg/m

Indexed as

Dietary FatsEnergy MetabolismExerciseObesityAdultCalorimetryFemaleHumansMaleDietary Fatsexercisehigh‐fat dietinsulinmetabolic flexibilityobesityrespiratory quotientsubstrate oxidationweight reductionwhole room calorimeter

Identifiers

PMID42322001

DOI10.14814/phy2.70979

PMCPMC13282261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.