Evidence map›Paper›PMID 42321942›Full record

ArticleJournal of cannabis research2026

Effect of vaporized Cannabidiol (CBD) on neuropathic pain and its potential implication for development of chronic lung inflammation in rats.

Priyadarshini Dutta, Ignacio Javier Novoa Cornejo, Vijaya Prakash Krishnan Muthaiah, Ravikumar Aalinkeel, Tracey A Ignatowski, Supriya D Mahajan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cannabis research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priyadarshini DuttaDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical Translational Research Center, University at Buffalo, The State University of New York, Buffalo, NY, 14203, USA.
Ignacio Javier Novoa CornejoDepartment of Rehabilitation Science, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 633 Kimball Tower, Buffalo, NY, 14214, USA.
Vijaya Prakash Krishnan MuthaiahDepartment of Rehabilitation Science, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 633 Kimball Tower, Buffalo, NY, 14214, USA.
Ravikumar AalinkeelDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical Translational Research Center, University at Buffalo, The State University of New York, Buffalo, NY, 14203, USA.
Tracey A IgnatowskiDepartment of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Room 4256, 955 Main Street, Buffalo, NY, 14203, USA. tai1@buffalo.edu.
Supriya D MahajanDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical Translational Research Center, University at Buffalo, The State University of New York, Buffalo, NY, 14203, USA.

Funding

A novel phase and spectroscopic imaging technique to evaluate mitochondrial dynamicsR01DA047410 · NIDA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI KHMALADZE, ALEXANDER, MAHAJAN, SUPRIYA DINKAR · 2019 to 2021
$1.1M
NIDA NIH HHS R01 DA047410NIH- National Institute of Drug Abuse 5R01DA047410-02University at Buffalo's Center for Cannabis and Cannabinoid Research 1179208-1-75023
6 · The paper itself

Abstract

backgroundCannabidiol (CBD) use in e-cigarettes is increasing, and its vaping involves using CBD in conjunction with other chemical additives such as propylene glycol (PG), vegetable glycerin (VG) and food flavorings, which help vaporize the CBD and enhance the vaping experience. Chronic neuropathic pain is challenging to treat with current medications, and there is growing interest in the use of medical cannabis for this condition. While the effects of vaping CBD could be beneficial for people with neuropathic pain, the potential detrimental effects on the lungs after continued exposure are not fully known. Whereas acute respiratory failure has been associated with vaping Cannabis, this study was undertaken to assess effects of CBD vaping on lung pathology and analgesic effectiveness in rats with sciatic nerve chronic constriction injury and examine potential mechanisms underlying the pathophysiology associated with CBD vaping.

methodsWe used an in-house designed and assembled prototype of an automated vaping exposure system that enables precise quantitation of vaping for in-vivo exposure of rats with neuropathic pain.

resultsOur results showed that CBD vapor exposure significantly alleviated pain, and modulation of cytokines and the NLRP3 (NOD-like receptor family, pyrin domain-containing 3) inflammasome pathway may underlie the CBD-induced effects in lung tissue, thereby affecting lung pathophysiology. Further, exposure to chemical additives like PGVG (Propylene Glycol and Vegetable Glycerin) resulted in a substantial inflammatory response indicating that these substances are by no means safe additives in e-cigarettes.

conclusionsThus, while CBD vaping may be beneficial in the management of neuropathic pain, it may cause substantial lung injury by promoting significant inflammatory changes in the lung.

Indexed as

AnalgesiaCannabidiolE-CigarettesLung InflammationNeuropathic PainVaping

Identifiers

PMID42321942
PMCPMC13531760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.