Evidence map›Paper›PMID 42321902›Full record

ArticleTrials2026

Integrative Music Therapy for Depression-related Disorders (iMTDep) - study protocol for a randomised controlled trial.

Esa Ala-Ruona, Tiia-Liina Raittila, Marianne Taipale, Nandhini Natarajan, Martin Hartmann, Anastasios Mavrolampados, Alessandro Ansani, Eliisa Löyttyniemi, Jaakko Erkkilä

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Esa Ala-RuonaThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland. esa.ala-ruona@jyu.fi.ORCID http://orcid.org/0000-0003-3873-5179
Tiia-Liina RaittilaThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0009-0000-6339-5570
Marianne TaipaleThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-5328-4313
Nandhini NatarajanThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0009-0007-6803-0272
Martin HartmannThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-2897-0610
Anastasios MavrolampadosThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-4554-0751
Alessandro AnsaniThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-0657-5732
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.ORCID http://orcid.org/0000-0002-7278-6511
Jaakko ErkkiläThe Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0003-1130-837X

Funding

Academy of Finland 346210
6 · The paper itself

Abstract

backgroundDepression, anxiety and work-related stress affect a significant number of adults disrupting their productivity, ability to function and attend work. These highly comorbid disorders tend to be difficult to treat effectively, and more information about integrative treatment approaches is needed. This study investigates the effectiveness of music therapy in treating depression-related disorders. METHODS/

designThe intervention is targeted at people of 18-65 years of age who are in employment, in their studies, temporarily unemployed, on short-term sick leave or rehabilitation allowance and suffer from depression-related disorders, which include one or several of the following: depression, anxiety, work-related stress or exhaustion. The interventions applied are Integrative Improvisational Music Therapy (IIMT) with or without the additional elements of music listening and vibroacoustic treatment. All sessions will begin with a preparative exercise called Resonance Frequency Breathing to enhance the effect of the therapy. All participants will receive the intervention for 6 weeks (60-min therapy session twice a week). The participants will be randomised into four groups that will have different modifications of the intervention, and the group without additional elements will serve as a waiting-list control group. The primary outcome will measure psychological distress. Secondary outcomes will address depression, anxiety, exhaustion, burnout, health-related quality of life and challenges in recognising emotions (alexithymia). DISCUSSION: The trial will elevate our understanding of the efficacy of integrative improvisational music therapy for depression-related disorders. Results will give more information about the combinations of additional elements used as part of the intervention. Extensive dataset will allow us to investigate the dynamics of therapeutic change and the factors that predict certain responsiveness to the intervention or explain the effects.

trial registrationProspectively registered on ISRCTN on 12.04.2024 (ISRCTN26812986). Study was approved by the Regional Medical Research Ethics Committee of Wellbeing Services County of Central Finland 15.02.2024 (ref: 7U/2023).

Indexed as

DepressionMusic TherapyAdolescentAdultAgedFemaleHumansMiddle AgedQuality of LifeRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeYoung AdultAnxietyClinical improvisationClinical studyDepressionMusic listeningMusic therapyRandomised controlled trialVibroacoustic treatmentWork-related stress

Identifiers

PMID42321902
PMCPMC13527921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.