Evidence map›Paper›PMID 42321862›Full record

ArticleJournal of translational medicine2026

Pomalidomide significantly enhances the antitumor immune efficacy of dendritic cell-derived exosomes from multiple myeloma patients.

Hu Zhang, Yifan Wang, Xueqing Wang, Hailing Duan, Duonan Yu, Xiaochuan Kuang, Lin He, Wenyi Zhang, Jie Chen, Jingying Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hu Zhang *Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Yifan Wang *Department of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Xueqing Wang *Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Hailing DuanDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Duonan YuDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Xiaochuan KuangDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Lin HeDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Wenyi ZhangCentral Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Jie ChenCentral Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China. georgechen811019@126.com.
Jingying DaiDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China. 741107213@qq.com.ORCID 0000-0002-9485-8686

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the effect and mechanism of pomalidomide on the immune activity of dendritic cell-derived exosomes (DEXs) from patients with multiple myeloma (MM).

methodsMoDCs were induced from monocytes obtained from patients with MM and HDs with or without pomalidomide treatment. DEXs were then isolated from culture supernatants via ultracentrifugation and characterized by TEM and NTA. Surface markers (CD63, CD81, CD80, CD86, and HLA-DR) were analyzed using nanoflow cytometry. Functional assays included coculturing DEXs with autologous PBMCs to activate T cells, followed by sorting CD8

resultsPomalidomide significantly increased the proportion of DEXs derived from patients with multiple myeloma (MM) and increased the expression levels and mean fluorescence intensity (MFI) of surface activation markers, including CD80, CD86 and HLA-DR. Functional assays demonstrated that DEXs treated with pomalidomide promoted the generation of CD8

conclusionsThis study provides a new strategy for enhancing the activity of DEXs derived from patients with MM, with the potential to develop DEXs as an antitumor vaccine for MM.

Indexed as

Antineoplastic AgentsDendritic CellsExosomesMultiple MyelomaThalidomideApoptosisCD8-Positive T-LymphocytesCell Line, TumorHumansLymphocyte ActivationMicroRNAsSignal TransductionAntineoplastic AgentsMicroRNAspomalidomideThalidomideAntitumor immune efficacyDendritic cell-derived exosomesMultiple myelomaPomalidomideT cell

Identifiers

PMID42321862
PMCPMC13543554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.