Evidence map›Paper›PMID 42321847›Full record

Trial reportCancer imaging : the official publication of the International Cancer Imaging Society2026

Prospective exploratory pilot study of 18 F-FMISO PET/CT for assessing tumor hypoxia in soft tissue sarcomas.

Ronnie Sebro, Ashley M Fuller, T S Karin Eisenger-Matheson, Christina Dulal, Austin R Pantel, Jacob Shabason, William Levin, Kumarasen Cooper, Paul Zhang, Daniel A Pryma and 3 more

Abstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer imaging : the official publication of the International Cancer Imaging Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ronnie SebroDepartment of Musculoskeletal Imaging, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1475, Houston, TX, 77030, USA. rsebro@gmail.com.
Ashley M FullerDepartment of Cancer Cell Biology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
T S Karin Eisenger-MathesonDepartment of Cancer Cell Biology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Christina DulalDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Austin R PantelDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Jacob ShabasonDepartment of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
William LevinDepartment of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Kumarasen CooperDepartment of Pathology, University of Pennsylvania, 3939 Market Street, Philadelphia, PA, 19104, USA.
Paul ZhangDepartment of Pathology, University of Pennsylvania, 3939 Market Street, Philadelphia, PA, 19104, USA.
Daniel A PrymaDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Michael D FarwellDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Jacob G DubroffDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
David A MankoffAbramson Cancer Center, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Funding

Deep learning for opportunistic screening for osteoporosis and osteopenia from radiographsR01EB035231 · NIBIB · MAYO CLINIC JACKSONVILLE · PI SEBRO, RONNIE · 2024 to 2024
$392k
Foundation for the National Institutes of Health R01 EB035231NIBIB NIH HHS R01 EB035231
6 · The paper itself

Abstract

Hypoxia is associated with poor outcomes in soft tissue sarcoma (STS) and is linked to increased expression of hypoxia-inducible factor 1-alpha (HIF-1α), carbonic anhydrase IX (CAIX), and lysyl hydroxylase 2 (PLOD2). These factors are potential therapeutic targets. This exploratory study aimed to investigate the correlation between

Indexed as

MisonidazolePositron Emission Tomography Computed TomographySarcomaTumor HypoxiaAdultAgedAntigens, NeoplasmBiomarkers, TumorCarbonic Anhydrase IXFemaleFluorodeoxyglucose F18HumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedPilot ProjectsAntigens, NeoplasmBiomarkers, TumorCA9 protein, humanCarbonic Anhydrase IXFluorodeoxyglucose F18fluoromisonidazoleHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMisonidazoleRadiopharmaceuticals

Identifiers

PMID42321847
PMCPMC13536671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.