Evidence map›Paper›PMID 42321813›Full record

ArticleJournal of nanobiotechnology2026

Radionuclide-labeled oxygen-self-supplying calcium reservoir for high-efficiency radioimmunotherapy via synergistic pyroptosis activation and PD-L1 downregulation.

Lin Liu, Kaiyan Huang, Hanjing Guo, Linping He, Xin Wang, Chao Wang, Jianqing Lin, Naihan Huang, Weibing Miao

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin Liu *Department of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Kaiyan Huang *Department of Breast Surgery, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. kaiyan_huang@126.com.
Hanjing GuoDepartment of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Linping HeDepartment of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Xin WangDepartment of Breast Surgery, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Chao WangDepartment of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Jianqing LinDepartment of Breast Surgery, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. dr_jianqinglin@163.com.
Naihan HuangDepartment of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. hnh@fjmu.edu.cn.
Weibing MiaoDepartment of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. miaoweibing@126.com.

Funding

Fujian Provincial Clinical Key Specialty Construction Project 2023SZDZK-HYXKNational Natural Science Foundation of China 82472012Natural Science Foundation of Fujian Province 2025J08172Science and Technology Innovation Joint Fund Project of Fujian Province 2025Y9164Technology Innovation Joint Fund Project of Fujian Province 2023Y9249
6 · The paper itself

Abstract

Internal radiation therapy is an irreplaceable modality for local tumor treatment, offering high-effective radiotherapy while sparing surrounding healthy tissues. However, current clinical non-biodegradable radionuclide implants suffer from permanent retention risks and limited efficacy against distal tumors due to inadequate immune activation. Herein, we engineered a biodegradable radionuclide-labeled oxygen-self-supplying calcium reservoir (

Indexed as

B7-H1 AntigenCalciumIodine RadioisotopesOxygenPyroptosisRadioimmunotherapyAnimalsCell Line, TumorDown-RegulationHumansHydrogen PeroxideMiceMice, Inbred BALB CTumor MicroenvironmentB7-H1 AntigenCalciumHydrogen PeroxideIodine-131Iodine RadioisotopesOxygenBiodegradableHypoxiaImmunotherapyPyroptosisRadiotherapy

Identifiers

PMID42321813
PMCPMC13527990

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.