Evidence map›Paper›PMID 42321800›Full record

ArticleJournal of nanobiotechnology2026

pH-responsive in situ antigen capture and cytosolic delivery synergize to elicit robust systemic antitumor immunity.

Zhuoling Bi, Shucheng Zhang, Guanyu Jin, Zhaofan Yang, Shanyi Lin, Lanqing Wang, Bingzheng Yu, Luyao Wang, Yuanzhen Su, Sijun Xiang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhuoling Bi *Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Shucheng Zhang *School of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Guanyu JinSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Zhaofan YangSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Shanyi LinSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Lanqing WangSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Bingzheng YuSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Luyao WangSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Yuanzhen SuSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Sijun XiangSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Xinyu XiangSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Letian LvSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Tianlin LaoSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China.
Jianfeng ZhouKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Shixian LvSchool of Materials Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking University, Beijing, 100871, China. lvshixian@pku.edu.cn.
Xiaozhi RongKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. rongxiaozhi@ouc.edu.cn.ORCID http://orcid.org/0000-0002-8252-6289

Funding

Henan Provincial Science and Technology Research Project 242300421207Ministry of Science and Higher Education of the Russian Federation 075-15-2025-639National Key Research and Development Program of China 2025YFE0114200National Natural Science Foundation of China 52273114, 32571686Open Project Program of Yaoshan laboratory 2024001
6 · The paper itself

Abstract

In situ cancer vaccines hold strong potential for addressing tumor heterogeneity by using the patient's own tumor as a personalized antigen source. However, their efficacy remains limited by insufficient antigen capture and inefficient cytosolic delivery. Here, we report an in situ antigen capture and delivery platform, DOX/PDiT@Gel, in which the pH-responsive function is provided by the polymer PDiT, while the hydrogel serves as a local retention matrix. In this system, doxorubicin (DOX) and a cationic polymer, PEG-DIPAMA-TAT (PDiT), are co-encapsulated within an oxidized dextran/carboxymethyl chitosan hydrogel. DOX induces immunogenic cell death, releasing diverse tumor antigens, while PDiT captures these antigens in situ via electrostatic interactions and promotes endo/lysosomal escape under acidic conditions. The hydrogel allows localized delivery of the therapeutic components at the postoperative tumor site. In vitro studies showed that PDiT markedly promoted antigen internalization, cross-presentation, and dendritic cell maturation. In murine models of postoperative recurrence and bilateral breast tumors, local treatment with DOX/PDiT@Gel inhibited the growth of both recurrent and distant tumors, together with stronger dendritic cell activation and enhanced memory T cell responses. Overall, this platform effectively amplifies antitumor immunity and offers a versatile strategy for personalized cancer immunotherapy.

Indexed as

Antigens, NeoplasmCancer VaccinesCytosolAnimalsCell Line, TumorDendritic CellsDextransDoxorubicinFemaleHumansHydrogelsHydrogen-Ion ConcentrationImmunotherapyMiceMice, Inbred C57BLPolyethylene GlycolsAntigens, NeoplasmCancer VaccinesDextransDoxorubicinHydrogelsPolyethylene GlycolsAntigen captureEndo/lysosomal escapeImmunotherapyIn situ cancer vaccinesPolymer

Identifiers

PMID42321800
PMCPMC13527964

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.