ReviewBMC biology2026
Immunomodulatory role and therapeutic potential of thrombospondin-1 during infectious diseases and autoimmunity.
Review in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infectious diseases and autoimmunity are leading causes of mortality worldwide. The lack of vaccines and resistance to current treatments by microbes highlight the importance of developing novel therapeutics. Similarly, treatments for autoimmune diseases are limited and require improved approaches. Identifying relevant proteins involved in host defense and tolerance to self-antigens is key to designing novel therapeutic strategies. Thrombospondin-1 (TSP-1) is a host glycoprotein involved in host defense and inflammation. Here, we analyze how TSP-1 interacts with different ligands involved in immunity. Then, we discuss the roles of TSP-1 in infection and autoimmunity to finally examine the therapeutic potential of TSP-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.