ArticleBMC musculoskeletal disorders2026
Subcutaneous extraskeletal osteosarcoma of the gluteal region: a case report from a resource-limited setting.
Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExtraskeletal osteosarcoma (ESOS) is a rare high-grade malignant mesenchymal tumor that produces osteoid in soft tissue without skeletal involvement. Subcutaneous ESOS is exceptionally uncommon and may mimic benign soft tissue lesions. CASE PRESENTATION: A 45-year-old Samoan man presented with a one-year history of a progressively enlarging, painless left gluteal mass. Contrast-enhanced CT showed a well-circumscribed subcutaneous lesion measuring 9.1 × 10.4 × 8.6 cm, with mild to moderate delayed enhancement and no osseous involvement. The tumor was surgically excised. Histopathology showed a spindle to pleomorphic high-grade sarcoma with osteoid produced by atypical tumor cells. Immunohistochemistry showed SATB2 positivity and negative staining for S100, SOX10, pan-cytokeratin, and ERG. The tumor involved the deep resection margin, consistent with R1 resection; the closest margin distance was not specified. The patient declined adjuvant therapy and was subsequently lost to follow-up.
conclusionsSubcutaneous ESOS is rare and diagnostically challenging. This case highlights the importance of imaging, histopathology, immunohistochemistry, and multidisciplinary management, particularly in resource-limited settings.
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