Trial reportBMC pregnancy and childbirth2026
Evaluation of an e-health integrated intervention for pregnant women with co-occurring mental health and substance use symptoms: an exploratory randomized clinical trial.
Trial report in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06965270 (Woman Mental Health and Addictions on Pregnancy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Woman Mental Health and Addictions on Pregnancy
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Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundThe co-occurrence of substance use and mental health problems in pregnant women implies higher maternal-foetal morbidity, and treatments often do not meet care needs. This study aims to generate preliminary evidence and hypothesis by exploring the potential effect of an integrated intervention based on third-generation therapies by comparing a telephone intervention with a digital intervention and treatment as usual.
methodsIn an exploratory randomised trial, 111 pregnant women (out of 2014 screened) with co-occurring mental health and substance use symptoms were assigned to either telephone-delivered intervention, digitally-delivered intervention, or treatment as usual groups. Interventions, based on third-generation therapy, lasted eight weeks. Outcomes (alcohol, tobacco use, depression, anxiety, and trauma) were measured at baseline and after two, four, eight, and twelve months.
resultsThe telephone intervention group performed significantly better with regard to alcohol, depression, and trauma symptoms after two and four months compared to the digital intervention and treatment as usual groups. The digital intervention group showed limited benefit and higher attrition. All groups had returned to baseline by the 12 month point.
conclusionsStandardised clinical interventions delivered by telephone can improve the treatment outcomes of pregnant women with co-occurring mental health and substance use problems. New approaches are needed to effectively implement these interventions via digital support.
trial registrationClinicalTrials.gov ID NCT06965270 (retrospectively registered in May 11, 2025).
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