Trial reportBMC oral health2026
Anti-plaque efficacy of two commercially available dentifrices in orthodontic patients. A randomized controlled clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study compares the anti-plaque efficacy of two commercially available dentifrices containing natural salivary enzymes in patients undergoing fixed orthodontic therapy. METHODOLOGY: This prospective, parallel- arm, double-blind, randomized controlled trial included 54 participants undergoing fixed orthodontic therapy who were diagnosed with moderate to severe gingivitis and were randomly allocated into three groups (n = 18 per group). Group A received Dente 91
resultsStatistical analysis demonstrated significant differences between and within the three experimental groups at different time intervals with the level of significance set at p < 0.05. Both enzyme-based dentifrices (Groups A and B) showed significantly greater improvements in PI, GI, and BOP compared to the Group C (control) (p < 0.05). The salivary biomarkers, AOPP significantly decreased in Groups A and B (p = 0.0002), compared to Group C at 24th week study interval. Strong positive correlations were found between clinical indices (PI, GI, BOP) and AOPP (p < 0.001) whereas MPO levels did not exhibit a significant correlation (p = 0.76) with any of the measured clinical parameters at study time points.
conclusionThese findings suggest that enzyme-based dentifrices provide effective plaque control and may additionally contribute to reduction in oxidative stress, thereby offering dual benefits for patients undergoing orthodontic treatment. This clinical trial was prospectively registered on 21st July 2023 with the Clinical Trials Registry- India (CTRI/2023/07/055494).
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