ArticleAAPS PharmSciTech2026
Eigenrate-Based Thermodynamic Decomposition of Competing Release Mechanisms in Polymeric Nano- and Microspheres: The MMIR-S Framework with Arrhenius Dual-Population Burst Kinetics and Log-Normal Polydispersity Averaging.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Modeling Bioactive Release from Cyclodextrin Complex-Loaded Polymeric Films: A Unified Theoretical Framework Integrating Host-Guest Thermodynamics, Partitioning, and Multi-Mechanism Transport.AAPS PharmSciTech · 2026Article
- A Rate-Weighted Framework for Diffusion, Swelling, and Erosion in Monolithic Polymeric Devices: Geometry-Unified Analytical Forms and a priori Mechanism Weights from Polymer-Solvent Thermodynamics.Pharmaceutical research · 2026Article
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Abstract
Simultaneous operation of Fickian diffusion, swelling-mediated relaxation, and polymer erosion in polymeric nano- and microspheres produces release profiles whose mechanistic origins cannot be resolved by empirical models without system-specific refitting. I present the Modified Multicomponent Interactive Release for Spheres (MMIR-S) framework, a thermodynamically self-consistent mechanistic model for homogeneously loaded spherical particles that determines mechanism-specific release weights from tabulated molecular descriptors, without fitting to release data. The theoretical core is Thermodynamic Eigenrate Decomposition (TED), in which each mechanism is assigned a commensurable first-order depletion rate: the diffusion eigenrate (π
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