Effect of GLP-1 receptor agonists at doses for obesity management on muscle health: systematic review and meta-analysis of randomized controlled trials (RCTs).

What the trial testedrandomised · 821 people · 2026

Randomised comparison

+1.81percentage points+1.10 to +2.52

As reported

difference 1.81 %, 95% CI 1.10–2.52

Randomised comparison

−5.44kg−7.07 to −3.81

As reported

difference −5.44 kg, 95% CI −7.07 to −3.81

the abstract, start to end

… weight, with an observed increase of 1.81% (95% CI: 1.1- 2.52; …

… in absolute lean mass, with a loss of -5.44 kg (95% CI: -7.07 to -3.81; …

← favours treatmentfavours comparator →

could be chance

Body weight & composition

1.811.10–2.52

Body weight & composition

−5.44−7.07 to −3.81

GLP-1 receptor agonistsBody weight & composition

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely

0.91not counted

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more certainless certain

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