Evidence map›Paper›PMID 42321471›Full record

ArticleNature neuroscience2026

Voltage dynamics of cortical dendrites in vivo.

J David Wong-Campos, Pojeong Park, Byung Hun Lee, Hunter C Davis, Yitong Qi, He Tian, Daniel G Itkis, Doyeon Kim, Jonathan B Grimm, Sarah E Plutkis and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

J David Wong-Campos *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8219-2944
Pojeong Park *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5574-6104
Byung Hun Lee *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0001-4846
Hunter C DavisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yitong QiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
He TianDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3282-7275
Daniel G ItkisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Doyeon KimDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0009-0001-8370-3160
Jonathan B GrimmJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-0331-4200
Sarah E PlutkisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0009-0003-1822-0466
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-0789-6343
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cohen@chemistry.harvard.edu.ORCID http://orcid.org/0000-0002-8699-2404

Funding

Two-Photon All-Optical Electrophysiology in Behaving MiceRF1NS126043 · NINDS · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2022 to 2022
$2.2M
Chemigenetic voltage indicators for far-red and two-photon imaging in vivoRF1NS133755 · NINDS · BROWN UNIVERSITY · PI ABDELFATTAH, AHMED · 2023 to 2023
$2.2M
Brain-wide correlation of single-cell firing properties to patterns of gene expressionRF1MH117042 · NIMH · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2018 to 2018
$1.2M
NIMH NIH HHS RF1 MH117042NINDS NIH HHS RF1 NS126043NINDS NIH HHS RF1 NS133755United States Department of Defense | United States Navy | Office of Naval Research (ONR) N00014-18-1-2859U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-MH117042U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-NS126043U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-NS133755
6 · The paper itself

Abstract

Voltage dynamics in dendrites, which result both from integrating synaptic inputs and back-propagating action potentials (bAPs) from the soma, contribute to plasticity. Mapping these dynamics in the dendritic arbors of live animals is crucial for understanding neuronal computation and plasticity rules. Here we combine targeted channelrhodopsin activation with dual-plane structured illumination voltage imaging for simultaneous monitoring of dendritic and somatic voltage response dynamics in cortical layer 2/3 pyramidal neurons in anesthetized and awake mice. We examined the integration of synaptic inputs and compared the dynamics of optogenetically evoked, spontaneous and sensory-evoked subthreshold and bAP dynamics. Our measurements revealed a broadly correlated membrane voltage throughout the dendritic arbor and only weak signatures of electrical compartmentalization within individual dendritic branches. However, we observed strong spiking-history-dependent modulation of bAP propagation into distal dendrites. We propose that this dendritic filtering of bAPs may have a critical role in the regulation of bursting and in activity-dependent plasticity.

Indexed as

Action PotentialsCerebral CortexDendritesPyramidal CellsAnimalsMiceMice, TransgenicNeuronal PlasticityOptogenetics

Identifiers

PMID42321471

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.