ArticleScientific reports2026
Chronic exposure to LED lighting impairs prefrontal cortex-dependent cognitive functions in adolescent rats.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The Light-emitting diodes (LEDs) have already replaced conventional lighting sources due to their energy efficiency and environmental benefits. Although previous studies suggest that chronic exposure to LED may affect human physiological health, its impact on cognitive functions remains unclear. To simulate typical human lighting conditions, we established an animal model which Sprague-Dawley (SD) rats exposed to LED light daily from 18:00 to 22:00 (ZT12-ZT16) for one month. Cognitive functions were assessed using social interaction, Morris water maze, and sound-location-association tasks. Results indicated that chronic LED exposure impaired social interaction ability, spatial learning and memory, and auditory-spatial associative learning. Immunohistochemical and Western blot analyses revealed a reduction in myelination levels and a decreased number of mature oligodendrocytes in the medial prefrontal cortex (mPFC). These findings suggest that chronic LED exposure impairs mPFC-dependent cognitive functions, possibly through downregulation of myelin integrity in the mPFC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.