Evidence map›Paper›PMID 42321441›Full record

ReviewNature reviews. Molecular cell biology2026

Regulation and function of specialized membrane protrusions in intercellular communication.

Shiyu Liu, Christina A Daly, Stacey K Ogden, Chiara Zurzolo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Emerging Roles of Cytoneme-Mediated Signaling in Cancer.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiyu LiuMembrane Traffic and Pathogenesis, Institut Pasteur, Université Paris Cité, CNRS UMR 3691, Paris, France.
Christina A DalyDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7470-0454
Stacey K OgdenDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Stacey.Ogden@stjude.org.ORCID http://orcid.org/0000-0001-8991-3065
Chiara ZurzoloMembrane Traffic and Pathogenesis, Institut Pasteur, Université Paris Cité, CNRS UMR 3691, Paris, France. chiara.zurzolo@pasteur.fr.ORCID http://orcid.org/0000-0001-6048-6602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells use specialized membrane extensions that enable the exchange of signals, organelles and other cargo to support long-range communication within complex tissues. Among these, tunnelling nanotubes, cytonemes and migrasomes have emerged as key contributors to development, immune responses and disease. Growing evidence has revealed that these structures are more prevalent and functionally diverse than previously appreciated, prompting a re-evaluation of how cells coordinate behaviour across space. In this Review, we discuss recent advances in understanding the formation, regulation and specificity of these dynamic connections, with an emphasis on tunnelling nanotubes and cytonemes, and highlight common principles underlying their architecture and cargo transfer. We further explore how their dysregulation contributes to pathology, underscoring the need to integrate these structures into current models of tissue organization.

Indexed as

Cell CommunicationCell MembraneCell Surface ExtensionsAnimalsCell Membrane StructuresHumansNanotubesSignal TransductionTunneling Nanotubes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.