ArticleCommunications biology2026
Analyzing cell migration history in vivo using fluorescent fibrillar collagen trails.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Cell migration is a critical process in development, homeostasis, and disease. While cell migration in vitro is well investigated, much less is known about migration deep within tissues, largely due to limitations associated with deep cell imaging in tissues. In this study, we investigated cell migration history in vivo by developing a strategy based on recording cell trails formed by fusion of fluorescent protein and collagen secreted by migrating cells. By engineering different cell lines to express either fluorescent protein-fused Col1a1 or Col1a2 we identified trails formed in normal mouse tissues as well as primary tumors and metastatic organ sites. Analyses of the trail patterns revealed the paths taken by migrating cells and regions that suggest group trails, including trails along vascular adventitia. These results demonstrate that cell migration history can be traced in mouse models through postmortem analysis of normal and cancerous tissues.
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