Evidence map›Paper›PMID 42321407›Full record

ArticleAnalytical and bioanalytical chemistry2026

AS1411 aptamer-functionalized, cell membrane-camouflaged nanoparticles for targeted tumor cells imaging in the Raman silent region.

Sihong Zheng, Ren Zhang, Wenjia Zhang, Ning Su, Mingxia Gao, Xiangmin Zhang

Abstract read
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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sihong ZhengCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China.
Ren ZhangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China.
Wenjia ZhangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China.
Ning SuCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China.
Mingxia GaoCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China. mxgao@fudan.edu.cn.
Xiangmin ZhangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, 201399, China.

Funding

National Key Research and Development Program of China 2024YFC3405400National Natural Science Foundation of China 22274027National Natural Science Foundation of China 22574027
6 · The paper itself

Abstract

Surface-enhanced Raman scattering (SERS) technology has attracted increasing attention in the field of biological imaging. Herein, we designed a new biomimetic SERS nanoprobe by sequentially modifying 4-mercaptobenzonitrile (4-MBN), cell membrane (CM), and AS1411 aptamer on the gold nanostars (Au@MBN@CM@apt) for synergistic targeted imaging of tumor cells. The Au@MBN@CM@apt probe integrates the distinctive functional properties of its constituent components. The internal gold nanostars (AuNS) with multi-tip structure significantly enhance the signal of Raman reporter molecules. Raman reporter molecule 4-MBN is adsorbed on the surface of AuNS, and its cyano group yields a characteristic Raman peak at 2226 cm

Indexed as

Aptamers, NucleotideCell MembraneMetal NanoparticlesNeoplasmsOligodeoxyribonucleotidesSpectrum Analysis, RamanAnimalsCell Line, TumorGoldHumansAGRO 100Aptamers, NucleotideGoldOligodeoxyribonucleotidesBiomimetic nanoparticlesRaman silent regionSERS imagingTargeted imagingTumor cells

Identifiers

PMID42321407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.