Evidence map›Paper›PMID 42321336›Full record

ReviewCommunications biology2026

The potential of methylation signal detection in eDNA toward functional ecological monitoring.

Chengbin Liu, Xia Fei, Itsuki T Hirayama, Genfu Yagi, Masayuki Ushio

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chengbin LiuDepartment of Ocean Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. cliuei@connect.ust.hk.ORCID 0009-0000-8207-3227
Xia FeiDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Itsuki T HirayamaInstitute of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan.
Genfu YagiFaculty of Science, University of the Ryukyus, Senbaru, Nishihara, Okinawa, Japan.
Masayuki UshioDepartment of Ocean Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. ong8181@gmail.com.ORCID 0000-0003-4831-7181

Funding

Research Grants Council, University Grants Committee (RGC, UGC) GRF16100724
6 · The paper itself

Abstract

Environmental DNA technology has revolutionized biomonitoring, primarily capturing the presence/absence of target taxa. Recent advances have revealed that eDNA also retains epigenetic signatures. In this perspective, we focus on DNA methylation signals in eDNA, which we define as meth-eDNA, and analyze three pivotal topics: (1) Detection of methylation signals in eDNA, (2) stability in aquatic environment, and (3) applications as ecological indicators. This perspective highlights the potential of meth-eDNA in non-invasive population-level trait inference. Future integration with multi-omics and sequencing innovations will achieve more precision in ecosystem conservation and management.

Indexed as

DNA, EnvironmentalDNA MethylationEnvironmental MonitoringAnimalsEcosystemEpigenesis, GeneticExtrachromosomal DNADNA, EnvironmentalExtrachromosomal DNA

Identifiers

PMID42321336
PMCPMC13282381

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.