ArticleScientific reports2026
Phytochemical profiling and integrated in vitro and in silico assessment of the antioxidant, thrombolytic, and anti-inflammatory properties of Urena lobata L. leaf extracts.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inflammation and fibrinolytic imbalance, which are frequently caused by oxidative stress and increased pro-inflammatory mediators, are major factors in the onset and progression of chronic illnesses. The study evaluated the phytochemical profile of Urena lobata L. leaf extracts using qualitative chemical tests and spectroscopic analysis, including FT-IR and MC-MS profiling. The pharmacological assessments were performed by antioxidant, anti-inflammatory, and thrombolytic capabilities of extracts using various in vitro assay methods along with in silico approaches, including molecular docking and ADMET-based pharmacokinetic assessments. The methanolic extract of Urena lobata L. (ULM) was fractionated using n-hexane, chloroform, ethyl acetate, and water to obtain the n-hexane (ULH), chloroform (ULC), ethyl acetate (ULE), and aqueous (ULW) fractions. Phytochemical analysis exhibited the presence of flavonoids, steroids, terpenoids, alkaloids, glycosides, and phenols in various fractions. FTIR analysis revealed the presence of a variety of groups, including aliphatic, aromatic, amide, nitrate, methylene, alcohols, phenols, etc. GC-MS study revealed significant bioactive chemicals, including β-amyrenonol acetate derivative, 14-deoxy-12-hydroxyandrographolide, 9,12-octadecadienoic acid, and N-(5-methyl-1,3-thiazol-2-yl)-2-phenylacetamide. In in vitro antioxidant assay, ULE had the highest antioxidant activity among the investment fractions, with IC
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