ArticleScientific reports2026
Distinct and common dynamics of central brain spontaneous neuronal activity across cell types during Drosophila pupal development.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The frequency or degree of spiking activity and its relative timing, in pre- and post- synaptic neurons is a major determinant of the nature of synaptic plasticity. Such activity driven plasticity based on stimuli forms the basis of learning and formation of memory. However, in the absence of any sensory stimuli particularly during development, neurons are active and often in a synchronous manner. Such spontaneous activity driven plasticity is thought to underlie formation and development of circuits. Drosophila has become the species of choice for many neural developmental studies due to ease of handling and genetics. However, little is known in terms of spontaneous activity in the central brain of the Drosophila pupa and how such activity is distinct in different cell types during development. In the current work, using two-photon Ca
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