Evidence map›Paper›PMID 42321205›Full record

ArticleNature communications2026

Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth.

Wataru Yamori, Issei Nakazato, Yuchen Qu, Yukina Sanga, Tomoko Miyata, Ryo Uehara, Yuma Noto, Keiichi Namba, Hiroshi Fukayama, Hiroyoshi Matsumura and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Chloroplasts and Plant Sustainability: Key Roles and Emerging Insights.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wataru Yamori *Graduate School of Agricultural and Life Sciences, Institute for Sustainable Agri-ecosystem Services, The University of Tokyo, Tokyo, Japan. yamori@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-7215-4736
Issei Nakazato *Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Yuchen QuGraduate School of Agricultural and Life Sciences, Institute for Sustainable Agri-ecosystem Services, The University of Tokyo, Tokyo, Japan.
Yukina SangaGraduate School of Agricultural and Life Sciences, Institute for Sustainable Agri-ecosystem Services, The University of Tokyo, Tokyo, Japan.
Tomoko MiyataGraduate School of Frontier Biosciences, The University of Osaka, Osaka, Japan.
Ryo UeharaCollege of Life Sciences, Ritsumeikan University, Shiga, Japan.
Yuma NotoCollege of Life Sciences, Ritsumeikan University, Shiga, Japan.
Keiichi NambaGraduate School of Frontier Biosciences, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0003-2911-5875
Hiroshi FukayamaGraduate School of Agricultural Science, Kobe University, Kobe, Japan.
Hiroyoshi MatsumuraCollege of Life Sciences, Ritsumeikan University, Shiga, Japan. h-matsu@fc.ritsumei.ac.jp.ORCID http://orcid.org/0000-0003-0361-3796
Shin-Ichi ArimuraGraduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. arimura@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-9537-1626

Funding

Japan Agency for Medical Research and Development (AMED) JP17pc0101020Japan Agency for Medical Research and Development (AMED) JP21am0101117 and JP22ama121003Japan Agency for Medical Research and Development (AMED) JP23ama121001MEXT | Japan Society for the Promotion of Science (JSPS) 21H02171MEXT | Japan Society for the Promotion of Science (JSPS) 22J20237MEXT | Japan Society for the Promotion of Science (JSPS) 24H02271MEXT | Japan Society for the Promotion of Science (JSPS) 24H02277MEXT | Japan Society for the Promotion of Science (JSPS) 25H02292, 24H02277, 24K01994, 23K18033 and 25H02292MEXT | Japan Society for the Promotion of Science (JSPS) JPJSCCA20230008MEXT | JST | Advanced Low Carbon Technology Research and Development Program (ALCA) JPMJAN25D2MEXT | JST | Program on Open Innovation Platform with Enterprises, Research Institute and Academia (OPERA) JPMJOP1861Osaka University (OU) CR-22-02 and CR-23-02
6 · The paper itself

Abstract

Photosynthetic inefficiencies limit the productivity and sustainability of crop production and the resilience of agriculture to future societal and environmental challenges. Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) has inherently low catalytic efficiency, making it a key target for photosynthesis and crop improvement. However, introducing mutations to the chloroplast-encoded Rubisco large subunit (rbcL), which contains the enzyme's catalytic sites, is technically challenging. In this study, we successfully generate a range of chloroplast-genome-edited Arabidopsis thaliana plants targeting rbcL by a targeted base editor, ptpTALECD. The M309I and D397N substitutions in rbcL result in an increased Rubisco catalytic rate (k

Indexed as

ArabidopsisChloroplastsGenome, ChloroplastPhotosynthesisRibulose-Bisphosphate CarboxylaseCarbon DioxideMutationPlants, Genetically ModifiedCarbon DioxideRibulose-Bisphosphate Carboxylase

Identifiers

PMID42321205
PMCPMC13282406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.