Evidence map›Paper›PMID 42321159›Full record

ArticleNature communications2026

Structure of the NAT10 acetyltransferase and mechanism of tRNA acetylation.

Mingyang Zhou, Supuni Thalalla Gamage, Khoa A Tran, David Bartee, Xuepeng Wei, Boyu Yin, Shelley Berger, Jordan L Meier, Ronen Marmorstein

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingyang ZhouDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Supuni Thalalla GamageChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Khoa A TranDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David BarteeChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Xuepeng WeiAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6514-7076
Boyu YinDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Shelley BergerDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5398-4400
Jordan L MeierChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA. jordan.meier@nih.gov.ORCID 0000-0002-0537-7101
Ronen MarmorsteinDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA. marmor@upenn.edu.ORCID 0000-0003-4373-4752

Funding

STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2008 to 2022
$28.3M
Targeting Cancer Through Modifications and MetabolismZIABC011488 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MEIER, JORDAN L · 2013 to 2025
$21.3M
Molecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer ReactionsR35GM118090 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein · 2016 to 2026
$6.7M
Project 4: Chromatin basis of cellular senescence and tissue agingP01AG092325 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 2026 to 2026
$5.6M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) P01 AG092325Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) P01 AG31862Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) P01AG31862Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R35 GM118090Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) ZIABC011488Intramural NIH HHS ZIA BC011488NIA NIH HHS P01 AG031862NIA NIH HHS P01 AG092325NIGMS NIH HHS R35 GM118090
6 · The paper itself

Abstract

NAT10 is the sole eukaryotic acetyltransferase that catalyzes N4-acetylcytidine (ac

Indexed as

ChaetomiumFungal ProteinsN-Terminal Acetyltransferase ERNA, TransferAcetylationCatalytic DomainCryoelectron MicroscopyCytidineHumansModels, MolecularN-Terminal AcetyltransferasesCytidineFungal ProteinsNAT10 protein, humanN-Terminal Acetyltransferase EN-Terminal AcetyltransferasesRNA, Transfer

Identifiers

PMID42321159
PMCPMC13433802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.