Evidence map›Paper›PMID 42321020›Full record

ArticleEuropean journal of haematology2026

Risk Factors of Blood Culture Positivity and Mortality in Bloodstream Infections: A Population-Based Study of Patients With B-Cell Malignancies.

Mathias Holmsgaard Eskesen, Alexander Djupnes Fuglkjær, Tarec Christoffer El-Galaly, Paw Jensen, Izabela Ewa Nielsen, Laurids Østergaard Poulsen, Mikkel Runason Simonsen, Kirstine Kobberøe Søgaard

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Article in European journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mathias Holmsgaard EskesenDepartment of Oncology, Clinical Cancer Research Centre, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0009-0005-0807-9352
Alexander Djupnes FuglkjærDepartment of Materials and Production, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0009-0000-3879-1950
Tarec Christoffer El-GalalyDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-4406-380X
Paw JensenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0000-0002-5248-0523
Izabela Ewa NielsenDepartment of Materials and Production, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0000-0002-3506-2741
Laurids Østergaard PoulsenDepartment of Oncology, Clinical Cancer Research Centre, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0000-0002-0466-976X
Mikkel Runason SimonsenDepartment of Haematology, Clinical Cancer Research Centre, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0009-0001-1119-4782
Kirstine Kobberøe SøgaardDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0000-0003-3624-7999

Funding

Danish Data Science Academy 2023-1210Sygeforsikringen "danmark" 2022-0086
6 · The paper itself

Abstract

backgroundBloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post-infection mortality in cancer patients.

methodsWe performed a cohort study of patients diagnosed with a B-cell malignancy in the North Denmark Region between 2013 and 2022, linking cancer registry data to health records. Causative pathogens were described. LASSO regression was used to select variables associated with PBCs and post-infection mortality. Odds ratios were estimated by univariate analyses.

resultsAmong 1592 patients with B-cell malignancies, 341 patients (21.4%) had at least one PBC, yielding 484 PBCs. We observed a shift from Gram-positive to Gram-negative dominance, driven by an increased frequency of the most common pathogen Escherichia coli (24.8%). Patients with neutropenia, elevated CRP, sepsis, hypotension, or kidney failure had a higher risk of a PBC. Advanced age, kidney failure, and sepsis were all associated with 30- and 90-day post-infection mortality.

conclusionRoutinely available parameters obtained at time of admission were associated with blood culture positivity and mortality. Our findings support the rationale for developing predictive models to individualise infection management.

Indexed as

BacteremiaBlood CultureLymphoma, B-CellSepsisAdultAgedAged, 80 and overDenmarkFemaleHumansMaleMiddle AgedPopulation SurveillanceRegistriesRisk Factorsbloodstream infectionchronic lymphocytic leukemiaepidemiologylymphomamicrobiologymortalitymultiple myelomaneoplasms

Identifiers

PMID42321020
PMCPMC13542935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.