Evidence map›Paper›PMID 42321015›Full record

ArticleExperimental physiology2026

Substrate-specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts.

Toan Pham

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Toan PhamAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-6323-9217

Funding

Health Research Council of New Zealand 21/653National Heart Foundation of New Zealand 1869
6 · The paper itself

Abstract

Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate-specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high-fat diet and low-dose streptozotocin. High-resolution respirometry and fluorimetry were used to measure mitochondrial O

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Mitochondria, HeartMyocardiumAdenosine TriphosphateAnimalsCitric Acid CycleEnergy MetabolismFatty AcidsMaleMembrane Potential, MitochondrialMetabolomicsOxidative PhosphorylationOxygen ConsumptionRatsRats, Sprague-DawleyAdenosine TriphosphateFatty AcidsReactive Oxygen Speciesadenosine triphosphatecardiac mitochondriametabolitemitochondrial respirationreactive oxygen speciestype 2 diabetes

Identifiers

PMID42321015
PMCPMC13394025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.