ArticleJournal for immunotherapy of cancer2026
Comprehensive characterization of the inflammatory ecosystems in immunotherapy-induced adverse events versus chronic inflammatory diseases.
Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comprehensive characterization of the inflammatory ecosystems in immunotherapy-induced adverse events versus chronic inflammatory diseases.Journal for immunotherapy of cancer · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundImmune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) share symptomatic and therapeutic similarities with chronic inflammatory diseases (CIDs). However, the molecular distinctions between irAEs and CIDs remain unclear. Herein, we systematically compared irAEs and CIDs across multiple tissues using large-scale multi-omics profiling.
methodsWe compiled a transcriptomic compendium of over 4.3 million cells from 1137 samples and 24 spatial transcriptomes across diverse inflammatory sites in irAEs and CIDs. In addition, we collected 526 pre-ICI and post-ICI treatment-matched blood transcriptomes coupled with germline exomes, alongside 75 serum proteomes with irAE information.
resultsHallmark gene signatures and cell states that characterize the inflammatory milieu of various irAEs and CIDs were defined. Across tissues, irAEs involve a distinct inflammatory ecosystem enriched with myeloid-derived components, including
conclusionsOur multimodal analyses highlight key differences between irAEs and CIDs, indicating that irAEs constitute a distinct inflammatory ecosystem that differentiates them from CIDs. Our study provides insights into potential biomarkers and therapeutic targets for improved irAE management.
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