Evidence map›Paper›PMID 42320802›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2026

Oligodendrocyte integrin-β1 regulates blood-brain barrier and remyelination in hemorrhagic brain.

Mehran Shaban Pour, Adil Moula, Ava Nasrollahi, Minkyung Kang, Yao Yao

Abstract read
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In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehran Shaban PourDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Adil MoulaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Ava NasrollahiDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Minkyung KangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA.
Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: yao7@usf.edu.

Funding

Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brainR01NS134134 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI Yao Yao · 2023 to 2026
$2.0M
Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationR01AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2024 to 2025
$1.2M
Brain extracellular matrix changes during normal aging and in Alzheimer diseaseR21AG091884 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2025 to 2025
$413k
NHLBI NIH HHS R01 HL146574NIA NIH HHS R01 AG065345NIA NIH HHS R21 AG091884NINDS NIH HHS R01 NS134134
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) causes high rates of mortality and long-term disability, but there are no effective treatments currently. Two key pathologies of ICH are blood-brain barrier (BBB) damage and white matter injury. Previous studies show that oligodendrocytes (OLs) regulate BBB integrity and (re)myelination via the extracellular matrix (ECM). The receptors that mediate these functions, however, remain incompletely understood. Here, we investigated the function of OL-derived integrin-β1 under both homeostatic and ICH conditions using conditional knockout mice. The mutant mice were grossly normal with intact BBB and OL maturation/myelination under homeostatic conditions. After ICH, however, these mutants exhibited exacerbated brain injury, including larger hematoma volume, elevated brain edema, aggravated axonal injury, enhanced BBB damage, compromised OL differentiation/maturation, impaired remyelination, and worsened neurological dysfunction. Subsequent studies revealed that the enhanced BBB injury was mediated by both paracellular and transcellular mechanisms and associated with pericyte defects. These findings demonstrate that OL-derived integrin-β1 is dispensable under homeostatic conditions but strictly required for BBB repair and remyelination following hemorrhagic stroke.

Indexed as

Blood-Brain BarrierCerebral HemorrhageIntegrin beta1OligodendrogliaRemyelinationAnimalsCell DifferentiationDisease Models, AnimalMiceMice, KnockoutPericytesIntegrin beta1Itgb1 protein, mouseBlood-brain barrierIntegrin-β1Intracerebral hemorrhageOligodendrocytes

Identifiers

PMID42320802
PMCPMC13681260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.