Evidence map›Paper›PMID 42320797›Full record

ArticleVirologica Sinica2026

Bruton's tyrosine kinase inhibitor BTKi-2 inhibits mpox virus and vaccinia virus infection.

Chen Yang, Runchu Zhao, Shuting Huo, Yaqing Zhang, Jingxi Feng, Mingli Gong, Lin Zhu, Conggang Zhang, Linqi Zhang, Jing Xue and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen YangSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Runchu ZhaoCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Shuting HuoSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Yaqing ZhangSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Jingxi FengSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Mingli GongSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Lin ZhuInstitute of Laboratory Animals Science, CAMS & PUMC, Beijing 100021, China.
Conggang ZhangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Linqi ZhangSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Jing XueInstitute of Laboratory Animals Science, CAMS & PUMC, Beijing 100021, China.
Rong ZhangSchool of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200433, China.
Qihui WangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Qiang DingSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China. Electronic address: qding@tsinghua.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent global outbreak of mpox virus (MPXV) infections underscores the urgent need for antiviral therapies against orthopoxviruses. In this study, using a high-content screening (HCS) platform based on a modified vaccinia virus Tiantan strain with GFP insertion (MVTT-GFP) under BSL-2 conditions, we screened 1513 kinase inhibitors for antiviral activity. Among these, Bruton's tyrosine kinase inhibitor BTKi-2 emerged as a potent candidate, exhibiting IC

Indexed as

Agammaglobulinaemia Tyrosine KinaseAntiviral AgentsEctromelia virusMonkeypox virusProtein Kinase InhibitorsVaccinia virusAnimalsCell LineDisease Models, AnimalFemaleHumansInhibitory Concentration 50MiceMpox, MonkeypoxVacciniaViral LoadAgammaglobulinaemia Tyrosine KinaseAntiviral AgentsProtein Kinase InhibitorsBTK inhibitor-2EGFRERBB2High-content screeningMpox virus (MPXV)Vaccinia virus (VACV)

Identifiers

PMID42320797
PMCPMC13469305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.