Evidence map›Paper›PMID 42320782›Full record

ReviewBiological psychiatry2026

Antipsychotic Drug Action, Novel Treatment Targets, and the Failure of Current Clinical Trial Designs in Evaluating New Target Molecules.

Anthony A Grace, Daniela L Uliana

Abstract readReview
In one paragraph

Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anthony A GraceDepartments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: graceaa@pitt.edu.
Daniela L UlianaDepartments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
Gating of Information Flow Within the Nucleus AccumbensR37MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRACE, ANTHONY A · 2007 to 2016
$3.3M
NIMH NIH HHS R01 MH057440NIMH NIH HHS R37 MH057440
6 · The paper itself

Abstract

The discovery of antipsychotic drugs more than 65 years ago revolutionized the treatment of schizophrenia that was initially based on serendipitous findings with chlorpromazine. This later led to the dopamine (DA) hypothesis, linking hyperdopaminergic states to psychosis. While D

Indexed as

AntipsychoticsClinical trialsD(2) antagonismDopamineHippocampusSupersensitivity

Identifiers

PMID42320782
PMCPMC13587369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.