Evidence map›Paper›PMID 42320662›Full record

ReviewRespiratory physiology & neurobiology

Oxygen extremes, inflammation, and neonatal breathing.

Ying-Jie Peng, Estelle Gauda, Nanduri R Prabhakar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Respiratory physiology & neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying-Jie PengInstitute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, The University of Chicago, Chicago, IL, USA.
Estelle GaudaHospital for Sick Children (SickKids), 555 University Ave., Room 38105 Atrium, Toronto, Ontario M5G 1X8, Canada.
Nanduri R PrabhakarInstitute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, The University of Chicago, Chicago, IL, USA. Electronic address: nanduri@uchicago.edu.

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2019 to 2023
$12.7M
NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454
6 · The paper itself

Abstract

Infants born prematurely often develop apnea of prematurity (AOP), characterized by periodic apneas with intermittent hypoxia (IH) and commonly treated with supplemental oxygen. On the other hand, infants born at high altitude experience sustained hypoxia from birth. Thus, during critical developmental period, many infants experience abnormal oxygen environments, including hypoxia or hyperoxia. Emerging evidence indicates that disrupted neonatal oxygen homeostasis can produce long-lasting effects on cardiorespiratory function. Preterm infants also exhibit systemic inflammation, and elevated inflammatory cytokines, which may influence respiratory control. This review summarizes clinical and experimental studies examining how neonatal extreme O

Indexed as

ApneaCarotid BodyHyperoxiaHypoxiaInflammationOxygenRespirationAnimalsHumansInfant, NewbornInfant, PrematureOxygenApnea of prematurityCarotid bodyHyperoxiaIntermittent hypoxiaSustained hypoxia

Identifiers

PMID42320662
PMCPMC13380301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.