Evidence map›Paper›PMID 42319948›Full record

ArticleScience advances2026

Architecture and function of holocentric CENP-A-independent inner kinetochores.

Christine Yu, Sundar Ram Sankaranarayanan, Gaetan Cornilleau, Anna C Howes, Caleigh M Azumaya, Eric S Day, Inna Zilberleyb, Bobby Brillantes, Tommy K Cheung, Leonie Dec and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Christine YuProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0009-0004-8294-4570
Sundar Ram SankaranarayananCNRS, UMR3664 Nuclear Dynamics Unit, Institut Curie, PSL Research University, Sorbonne Université, Paris 75005, France.ORCID 0000-0003-4408-5299
Gaetan CornilleauCNRS, UMR3664 Nuclear Dynamics Unit, Institut Curie, PSL Research University, Sorbonne Université, Paris 75005, France.
Anna C HowesProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-2709-9827
Caleigh M AzumayaProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-3484-9921
Eric S DayPharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Inna ZilberleybProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bobby BrillantesProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Tommy K CheungProteomic & Genomic Technologies, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Leonie DecCurieCoreTech Mass Spectrometry Proteomics, Institut Curie, PSL Research University, Centre de Recherche, 26 rue d'Ulm, Paris 75248 Cedex 05, France.ORCID 0009-0008-2475-0275
Damarys LoewCurieCoreTech Mass Spectrometry Proteomics, Institut Curie, PSL Research University, Centre de Recherche, 26 rue d'Ulm, Paris 75248 Cedex 05, France.ORCID 0000-0002-9111-8842
Phong TranDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19103, USA.
Christopher M RoseProteomic & Genomic Technologies, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-7502-3368
Ines Anna DrinnenbergCNRS, UMR3664 Nuclear Dynamics Unit, Institut Curie, PSL Research University, Sorbonne Université, Paris 75005, France.ORCID 0000-0002-9649-0352
Claudio CiferriProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-0804-2411
Stanislau YatskevichProtein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0003-2999-6561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetochores are essential macromolecular complexes anchoring chromosomes to the mitotic spindle, ensuring faithful cell division. Despite their critical role, the structural organization of kinetochores across diverse species remains poorly understood. We present the inner kinetochore constitutive centromere-associated network (CCAN) structure of the silkmoth

Indexed as

BombyxKinetochoresAnimalsCentromereChromosomal Proteins, Non-HistoneInsect ProteinsChromosomal Proteins, Non-HistoneInsect Proteins

Identifiers

PMID42319948
PMCPMC13281801

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.