Evidence map›Paper›PMID 42319936›Full record

ArticleScience advances2026

Mitotic Cdc42 waves encode PI(3,4)P

Suet Yin Sarah Fung, Shengping Xiao, Yujin Bao, Morven Graham, Maohan Su, Xinran Liu, Joerg Bewersdorf, Min Wu

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suet Yin Sarah FungDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9448-2826
Shengping XiaoCentre for Bioimaging Sciences, National University of Singapore, Singapore, Singapore.ORCID 0009-0005-2805-112X
Yujin BaoDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0536-8504
Morven GrahamDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4375-3198
Maohan SuDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5523-9607
Xinran LiuDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1586-2151
Joerg BewersdorfDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4085-7020
Min WuDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9161-7940

Funding

Endocytic dynamics and surface emergent property of leukocyte IntegrinsR01GM151344 · NIGMS · YALE UNIVERSITY · PI Min Wu · 2023 to 2026
$1.9M
NIGMS NIH HHS R01 GM151344
6 · The paper itself

Abstract

Self-organizing waves are observed in numerous biological systems and may encode spatial and temporal information for cellular organization in the absence of prepatterns. In mitotic mast cells, periodic cortical waves emerge before spindle assembly with wave periods that are proportional to cell size. Here, we investigate the mechanisms that govern cortical wave scaling and examine the consequence of wave perturbation on mitotic spindle size scaling. We find that the periods of mitotic waves are regulated by the turnover of phosphatidylinositol 3,4-bisphosphate [PI(3,4)P

Indexed as

Golgi ApparatusMitosisPhosphatidylinositol PhosphatesSignal TransductionSpindle ApparatusCell MembraneHumansPhosphoric Monoester Hydrolasesphosphatidylinositol-3,4-bisphosphate 4-phosphatasephosphatidylinositol 3,4-diphosphatePhosphatidylinositol PhosphatesPhosphoric Monoester Hydrolases

Identifiers

PMID42319936
PMCPMC13281794

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.