Evidence map›Paper›PMID 42319930›Full record

ArticleScience advances2026

Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish.

Tahnee Mackensen, Luis Pedro Iñiguez, Thomas Soares Mullen, Cristina Rodriguez-Marin, François Kroll, Giulia Zuccarini, Jordi Fernandez-Albert, Laia Sancho-Vila, Jon Permanyer, Isaac H Bianco and 3 more

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tahnee MackensenUniversitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-6537-7592
Luis Pedro IñiguezUniversitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-1470-9024
Thomas Soares MullenChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.ORCID 0000-0002-3695-4477
Cristina Rodriguez-MarinUniversitat Pompeu Fabra, Barcelona, Spain.
François KrollSorbonne Université, INSERM U968, CNRS UMR 7210, Institut de la Vision, Paris, France.ORCID 0000-0001-9908-2648
Giulia ZuccariniDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Jordi Fernandez-AlbertUniversitat Pompeu Fabra, Barcelona, Spain.
Laia Sancho-VilaUniversitat Pompeu Fabra, Barcelona, Spain.
Jon PermanyerCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.
Isaac H BiancoDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK.ORCID 0000-0002-3149-4862
Michael OrgerChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.ORCID 0000-0002-9763-8902
Jason RihelDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID 0000-0003-4067-2066
Manuel IrimiaUniversitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-2179-2567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper regulation of arousal maintains the balance of rest and activity and enables appropriate responses to stimuli; its disruption is a hallmark of many neurodevelopmental disorders. Although transcriptional mechanisms of arousal control are well defined, the contribution of posttranscriptional processes such as alternative splicing remains unclear. Here, we identify a critical role for the microexon splicing regulator

Indexed as

ArousalCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinExonsNeuronsSignal TransductionZebrafishZebrafish ProteinsAlternative SplicingAnimalsMutationPhosphorylationCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinZebrafish Proteins

Identifiers

PMID42319930
PMCPMC13281805

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.