In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
25 authors.
Nazli RobinDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0009-0007-9275-4510 Nicole G BarraDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0002-2605-0845 Kevin P FoleyDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Yujin E LiDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0009-0005-1733-6592 Danish PatoliCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France.ORCID 0000-0002-6837-336X Irena A RebalkaDepartment of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0002-4732-5473 Tabitha CreeMurdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.ORCID 0009-0007-7185-7078 Kaitlyn BibbyMurdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.
Khang NguyenDepartment of Biology, York University, Canada.
Rhianna DavisDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Darryl Y ChanDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0009-0008-8047-0454 Brittany M DugganDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Brandyn D HenriksboDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Megan E BorgesDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0009-0002-0139-1317 Dana Kukje ZadaDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0002-8403-1685 Han FangDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0002-0450-5087 Daniel M MarkoDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0001-6742-9731 Paul GregorevicCentre for Muscle Research Department of Anatomy and Physiology, The University of Melbourne, Melbourne 3010, Australia.ORCID 0000-0002-7418-8945 Kevin I WattNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.ORCID 0000-0001-7475-4487 Richard J MillsMurdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.ORCID 0000-0001-9735-2595 Thomas J HawkeDepartment of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0003-4974-4820 Bénédicte F PyCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France.ORCID 0000-0001-6716-7807 Jonathan D SchertzerDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.ORCID 0000-0002-1547-5856 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Statin intolerance and side effects such as low-level myopathy limit statin use and the dose for optimal cholesterol lowering. We found that priming the NLRP3 inflammasome with bacterial components like lipopolysaccharide lowered the dose of statins that caused side effects in muscle cells. We then built models of low-level statin myopathy and found that muscle cell-autonomous statin-induced myopathy occurs through the NLRP3 inflammasome in vitro and in mice. Statin-induced muscle cell death and higher
Indexed as
Adaptor Proteins, Signal TransducingHydroxymethylglutaryl-CoA Reductase InhibitorsMuscular DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinProtein PrenylationAnimalsCell Cycle ProteinsHumansInflammasomesMiceMuscle, SkeletalYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsHydroxymethylglutaryl-CoA Reductase InhibitorsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseYap1 protein, mouseYAP-Signaling Proteins
Identifiers
PMID42319925
PMCPMC13281816
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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