Evidence map›Paper›PMID 42319920›Full record

ArticleScience advances2026

Coxsackievirus B escapes antiviral CD8

Orlando Burgos-Morales, Federica Vecchio, Fatoumata Samassa, Margot Petit, Zhicheng Zhou, Barbara Brandao, Alexia Carré, Annalisa Nicastri, Valeriia Dotsenko, Chloe Shepherd and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Orlando Burgos-MoralesUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-5086-2675
Federica VecchioUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0003-4607-8818
Fatoumata SamassaUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-5877-0540
Margot PetitUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0009-0006-8797-1556
Zhicheng ZhouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-9137-7951
Barbara BrandaoUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0009-0008-0128-0100
Alexia CarréUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0001-8144-7194
Annalisa NicastriSchool of Life Sciences, University of Dundee, Dundee, Scotland, UK.
Valeriia DotsenkoFaculty of Medicine and Health Technology, Celiac Disease Research Center, Tampere University and Tampere University Hospital, Tampere, Finland.ORCID 0000-0002-0336-0533
Chloe ShepherdSchool of Life Sciences, University of Dundee, Dundee, Scotland, UK.ORCID 0000-0002-0149-7448
Keijo ViiriFaculty of Medicine and Health Technology, Celiac Disease Research Center, Tampere University and Tampere University Hospital, Tampere, Finland.ORCID 0000-0002-7167-5094
Robert ParkerCentre for Immuno-Oncology, University of Oxford, Oxford, UK.
Amelia K LinnemannCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-7356-4876
Sylvaine YouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-1578-5205
Malin Flodstrom-TullbergKarolinska University Hospital Huddinge, Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2685-2052
Nicola TernetteSchool of Life Sciences, University of Dundee, Dundee, Scotland, UK.ORCID 0000-0002-9283-0743
Roberto MalloneUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.ORCID 0000-0002-9846-8861

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coxsackieviruses B (CVBs) are plausible triggers of the pancreatic islet autoimmunity leading to type 1 diabetes. Islet autoantibody seroconversion correlates with persistent CVB infections in the gut and pancreas, suggesting defective antiviral control and the need to define immune mechanisms at the intestinal entry site. We investigated how CVB3 modulates antigen presentation, the viral immunopeptidome of enterocytes and antigen-presenting cells, and downstream T cell immunity. CVB3-infected enterocytes evaded immune recognition by down-regulating human leukocyte antigen (HLA) class I and viral peptide presentation, impairing CD8

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoxsackievirus InfectionsEnterovirus B, HumanImmunologic MemoryAntigen PresentationHumansLymphocyte Activation

Identifiers

PMID42319920
PMCPMC13281823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.