ArticleGenome biology and evolution2026
OrthoGuide: A Database for Rooting Inference of Orthologous Genes.
Article in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Orthology provides a powerful framework for investigating the evolutionary history of biological systems, as genes within the same orthologous group typically share a common ancestry. By tracing their distribution across species, it is possible to infer the evolutionary origin of genes and reconstruct the stepwise assembly of molecular pathways and regulatory networks. However, performing such analyses at scale often requires specialized computational tools and expertise, limiting their accessibility to a broader community. Here, we introduce OrthoGuide, a database and web application that provides precomputed evolutionary rooting information for orthologous groups across 360 eukaryotic species. The platform enables users to query gene sets and rapidly explore their evolutionary origins through an intuitive interface, without the need for local computational workflows. In addition to tabular outputs, OrthoGuide offers interactive visualizations that facilitate the interpretation of evolutionary patterns and the identification of key events in the emergence of biological systems. By removing technical barriers and standardizing large-scale evolutionary inferences, OrthoGuide enables researchers to translate gene lists into biologically meaningful hypotheses. This resource democratizes access to orthology-based evolutionary analyses and supports the investigation of system-level evolutionary processes across a wide range of organisms. The web application and the database are hosted at https://dalmolingroup.imd.ufrn.br/orthoguide/.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.