Evidence map›Paper›PMID 42319651›Full record

ArticleJournal of cardiovascular translational research2026

Pim1 Mitigates Heart Failure by Suppressing Ferroptosis Via Activation of the mTORC1/SLC7A11/GPX4 Axis.

Yunrui Zhang, Fanqi Kong, Weiwei Wang, Jiaxi Pan

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunrui ZhangDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Ruian District, Wenzhou, 325200, China.
Fanqi KongDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Ruian District, Wenzhou, 325200, China.
Weiwei WangDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Ruian District, Wenzhou, 325200, China.
Jiaxi PanDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, No.108 Wansong Road, Ruian District, Wenzhou, 325200, China. pjx19821213@163.com.ORCID 0009-0000-6589-6993

Funding

Wenzhou Science and Technology Bureau Y2023353
6 · The paper itself

Abstract

Heart failure (HF) remains a major cause of morbidity and mortality, with ferroptosis increasingly implicated in its progression. Pim1, a serine/threonine kinase, exerts cardioprotective effects by regulating cell survival and oxidative stress, but its role in ferroptosis during HF remains unclear. Here, HF was induced in rats by left anterior descending coronary artery ligation, followed by lentiviral-mediated Pim1 overexpression. Cardiac function, myocardial injury, fibrosis, and ferroptosis-related markers were evaluated. In vitro, H9C2 cardiomyocytes were exposed to H

Indexed as

FerroptosisHeart FailureMechanistic Target of Rapamycin Complex 1Myocytes, CardiacPhospholipid Hydroperoxide Glutathione PeroxidaseProto-Oncogene Proteins c-pim-1AnimalsCell LineDisease Models, AnimalFibrosisLipid PeroxidationMaleOxidative StressRatsRats, Sprague-DawleyReactive Oxygen SpeciesMechanistic Target of Rapamycin Complex 1Phospholipid Hydroperoxide Glutathione PeroxidasePim1 protein, ratProto-Oncogene Proteins c-pim-1Reactive Oxygen SpeciesCardiomyocyte injuryFerroptosisHeart failureMTORC1/SLC7A11/GPX4 axisPim1

Identifiers

PMID42319651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.