Evidence map›Paper›PMID 42319632›Full record

ArticleHead and neck pathology2026

DEK::AFF2 Fusion-Associated Nonkeratinizing Squamous Cell Carcinoma with Noncontiguous Middle Ear and Sinonasal Involvement.

Yan Li, Linxiang Ma, Wenlin Yang, Renya Zhang, Ting Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yan LiDepartment of Pathology, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, People's Republic of China.
Linxiang MaDepartment of Otolaryngology, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, People's Republic of China.
Wenlin YangDepartment of Pathology, Nantong Tumor Hospital Affiliated to Nantong University, Nantong, 226006, Jiangsu, People's Republic of China.
Renya ZhangDepartment of Pathology, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, People's Republic of China.
Ting WangDepartment of Pathology, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, People's Republic of China. jiningwangting@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDEK::AFF2 fusion-associated nonkeratinizing squamous cell carcinoma is a recently recognized HPV-independent entity characterized by deceptively bland morphology and potential mimicry of benign or inflammatory lesions. CASE PRESENTATION: A 21-year-old woman presented with recurrent left-sided otorrhea and progressive hearing loss. Imaging demonstrated noncontiguous lesions involving the left middle ear/mastoid compartment and the sinonasal region. Histologically, both lesions showed nonkeratinizing squamous proliferation with focal papillary/inverted architecture, mild to moderate cytologic atypia, and focal stromal invasion. Immunohistochemically, the tumor exhibited diffuse nuclear AFF2 expression, positivity for CK5/6 and p40, wild-type p53 expression, and negative p16 and INSM1. Targeted next-generation sequencing confirmed DEK::AFF2 fusion in both lesions.

conclusionThis case expands the anatomic spectrum of DEK::AFF2 fusion-associated nonkeratinizing squamous cell carcinoma by demonstrating noncontiguous middle ear and sinonasal involvement. Recognition of its characteristic morphologic, immunophenotypic, and molecular features is essential to avoid misdiagnosis.

Indexed as

Carcinoma, Squamous CellEar NeoplasmsParanasal Sinus NeoplasmsBiomarkers, TumorChromosomal Proteins, Non-HistoneDNA-Binding ProteinsEar, MiddleFemaleHumansNuclear ProteinsOncogene ProteinsOncogene Proteins, FusionPoly-ADP-Ribose Binding ProteinsYoung AdultAFF2 protein, humanBiomarkers, TumorChromosomal Proteins, Non-HistoneDEK protein, humanDNA-Binding ProteinsNuclear ProteinsOncogene ProteinsOncogene Proteins, FusionPoly-ADP-Ribose Binding ProteinsAFF2 immunohistochemistryDEK::AFF2 fusionDiagnostic pitfallMiddle earNonkeratinizing squamous cell carcinomaSinonasal tract

Identifiers

PMID42319632
PMCPMC13282426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.