Evidence map›Paper›PMID 42319540›Full record

ArticleMolecular neurobiology2026

Postbiotic Lactobacillus reuteri LRE02 Enriched with Sodium Selenite Demonstrates Antidepressant- and Anxiolytic-Like Effects in Mice.

Aline Silveira Gonçalves, Mariana Parron Paim, Narryman Pinto Zuge, Marcia Juciele da Rocha, Marcelo Heinemann Presa, Evelyn Mianes Besckow, Fábio Pereira Leivas Leite, Lucielli Savegnago, Fernanda Severo Sabedra Sousa, Fabiana Kommling Seixas and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aline Silveira GonçalvesLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Mariana Parron PaimLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Narryman Pinto ZugeLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Marcia Juciele da RochaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Marcelo Heinemann PresaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Evelyn Mianes BesckowLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Fábio Pereira Leivas LeiteGraduate Program in Biotechnology (PPGB), Center for Technological Development, Federal University of Pelotas, Pelotas, RS, Brazil.
Lucielli SavegnagoGraduate Program in Biotechnology (PPGB), Research Group On Neurobiotechnology - GPN, Center for Technological Development, Federal University of Pelotas, Pelotas, RS, Brazil.
Fernanda Severo Sabedra SousaGraduate Program in Biotechnology (PPGB), Research Group On Cellular and Molecular Oncology - GPO, Center for Technological Development, Federal University of Pelotas, UFPel, Pelotas, RS, Brazil.
Fabiana Kommling SeixasGraduate Program in Biotechnology (PPGB), Research Group On Cellular and Molecular Oncology - GPO, Center for Technological Development, Federal University of Pelotas, UFPel, Pelotas, RS, Brazil.
Tiago Veiras CollaresGraduate Program in Biotechnology (PPGB), Research Group On Cellular and Molecular Oncology - GPO, Center for Technological Development, Federal University of Pelotas, UFPel, Pelotas, RS, Brazil.
Gustavo GohlkeDepartment of Chemistry, Graduate Program in Chemistry (PPGQ), Federal University of Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Erico Marlon de Moraes FloresDepartment of Chemistry, Graduate Program in Chemistry (PPGQ), Federal University of Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Marcia Foster MeskoLaboratory of Control of Contaminants in Biomaterials (LCCBio), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Cristiani Folharini BortolattoLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Paloma Taborda BirmannLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil. paloma_birmann@hotmail.com.ORCID https://orcid.org/0000-0002-2035-5138
César Augusto BrüningLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil. cesar.bruning@ufpel.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postbiotics, including inactivated microorganisms and their bioactive components, have emerged as innovative candidates for microbiota-targeted therapies. Among them, Lactobacillus reuteri-derived postbiotics represent a promising and underexplored strategy for modulating host physiology without the risks associated with live bacteria. Selenium enrichment may further enhance these benefits by strengthening antioxidant defenses and regulating inflammation, two central mechanisms to microbiota-gut-brain axis communication. In this study, we investigated the antidepressant- and anxiolytic-like effects of L. reuteri LRE02 in three formulations: a live probiotic (Lr), an inactivated postbiotic (ILr), and a selenium-enriched postbiotic (ILr/Se) in male Swiss mice. Animals were assigned to five groups: vehicle, Lr, ILr, ILr/Se, and fluoxetine, and treated intragastrically for 14 days (300 μL, 10

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsLimosilactobacillus reuteriProbioticsSodium SeleniteAnimalsAnxietyBehavior, AnimalMaleMiceOxidative StressAnti-Anxiety AgentsAntidepressive AgentsSodium SeleniteInflammationLactobacillusNeuropsychiatric disordersOxidative stressPostbioticsSelenium

Identifiers

PMID42319540
PMCPMC13282309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.