Prevalence of methicillin-resistant coagulase-negative staphylococci and their antibiotic resistance profile in Zagazig University intensive care units.

Hend M Elarini, Sara M Gaafer, Fatma A Ibrahim, Nessma H Gandor, Walid M A Hamad, Samia Hussein, Aya M Bedawy

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Hend M ElariniDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Sara M GaaferDepartment of Anaesthesia, Intensive Care and Pain Management, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Fatma A IbrahimDepartment of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Nessma H GandorDepartment of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Walid M A HamadDepartment of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Samia HusseinMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. shmohammed@medicine.zu.edu.eg.

Aya M BedawyDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Funding

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6 · The paper itself

Abstract

backgroundCoagulase-negative staphylococci (CoNS) are important opportunistic hospital pathogens. Their ability to acquire antibiotic resistance, especially to methicillin, poses a challenge in clinical management. This study was conducted to determine the prevalence, antibiotic resistance, and genetic profiles of methicillin-resistant (MR) CoNS isolates causing infections in intensive care unit (ICU) patients. METHODS AND

resultsA total of 785 hospital-acquired infection samples were investigated, and 113 CoNS strains were identified out of them. Methicillin-resistant isolates were tested for the mecA and mecC genes by using polymerase chain reaction (PCR), followed by DNA sequencing to investigate potential genetic variations. Among the 113 CoNS isolates, 50 (44.2%) were identified as methicillin-resistant. Among these, S. epidermidis exhibited the highest rate of methicillin resistance. Vancomycin and linezolid resistance were each detected in 18% of the isolates. Most of the isolates (45/50, 90%) were multidrug-resistant (MDR), with a multiple-antibiotic resistance (MAR) index ranging from 0.27 to 1. The mecA gene was detected in all of the MR-CoNS isolates, whereas no isolate tested positive for the mecC gene. Nucleotide sequencing of the mecA gene in the selected MR-CoNS revealed high sequence similarity among different species.

conclusionsThe widespread presence of mecA and high rates of methicillin and multidrug resistance in CoNS emphasize the need for routine monitoring and infection control strategies in hospital settings.

Indexed as

Methicillin ResistanceStaphylococcal InfectionsStaphylococcusAnti-Bacterial AgentsBacterial ProteinsCoagulaseCross InfectionDrug Resistance, Multiple, BacterialHumansIntensive Care UnitsMethicillinMicrobial Sensitivity TestsPenicillin-Binding ProteinsPrevalenceVancomycinAnti-Bacterial AgentsBacterial ProteinsCoagulaseMethicillinPenicillin-Binding ProteinsVancomycinCoagulase-negative staphylococciCoNSmecAmecCMethicillin resistance

Identifiers

PMID42319522

DOI10.1007/s11033-026-12117-x

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