ArticleMikrochimica acta2026
A self-cascade nanozyme with glucose oxidase-/peroxidase-like activities via in situ growth of Au nanoparticles on CuMOF for colorimetric glucose detection.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of stable and efficient self-cascade catalytic systems for glucose detection remains a challenge in nanozyme-based sensing. Here, we report a self-cascade Au@CuMOF nanozyme, constructed by in-situ growth of gold nanoparticles (Au NPs) onto a copper-based metal-organic framework (CuMOF). The resulting Au@CuMOF possesses both glucose oxidase (GOx)-like activity derived from Au NPs and peroxidase (POD)-like activity derived from CuMOF. The negatively charged Au NPs electrostatically anchor onto the positively charged CuMOF surface, preventing aggregation and preserving their GOx-like activity. Leveraging these dual functionalities, Au@CuMOF enables a self-cascade reaction: the GOx-like activity catalyzes glucose oxidation to gluconic acid and H
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